I'm having the same problem, and I'm also on a Mac. The clue keeps pointing in the vicinity of the red pepper, but I've clicked all over there, and nothing comes up (except I keep losing time because I've clicked too much).
Having items appear at the edge of the screen is fine, but having them completely off-screen and inaccessible is an exercise in complete frustration, both from having to "guess" where the item is located and then not being able to get at it even with the clues.
Edited on 01/19/2009 at 7:10:47 AM PST