Welcome to The Pond, MrsWolfie09!
I don't know that I'm a "seasoned" player, but Cradle of Rome is one of my favorites. There is a whole forum page for it. If you click on the "All Game Forums" tab and then select the letter "C", you'll be able to scroll down to the specific forum.
I will tell you, that yes, when you get to certain levels and run out of lives, it will kick you all the way back to the beginning of that section (I believe there are 5 sections).
I have never gotten past level 96, at which point I get thrown back to level 71!
I love the game, though, so I keep trying.
As far as power up goes, after you pass a specific level and then achieve, let us say, a 15-symbol match, you will get a "power up". A little blurb will show up on the screen saying something like, "Congratulations, you now have a citizen farmer. This will speed up such-and-such" (let us say the bomb). At the bottom of the screen at the level you are on, there are little symbols - an axe, a bomb, etc. They will get brighter as they fill up so that you can use them. Some are more usefull than others.
I hope my rambling helps!
The waters here are happy and warm, and I hope you keep posting.
Fair